Explain what a type i hypersensitivity is, how ige antibodies are involved, and then connect this back to explain why desensitization can help reduce these hypersensitivities.

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Nov 11, 2022


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Study sources
The recommended reading for this week should be the main source you need. That is:
Open Educational ResourcesOpenStax Microbiology
Chapter 17: Innate Nonspecific Host Defenses (https://openstax.org/books/microbiology/pages/17-introduction)
Chapter 18: Adaptive Specific Host Defenses (https://openstax.org/books/microbiology/pages/18-introduction)
Libre Texts Biology 11.7B: Antibody genes and diversity (https://bio.libretexts.org/Bookshelves/Microbiology/Book%3A_Microbiology_(Boundless)/11%3A_Immunology/11.07%3A_Antibodies/11.7B%3A_Antibody_Genes_and_Diversity)
Chapter 19: Diseases of the Immune System (https://openstax.org/books/microbiology/pages/19-introduction)
There may be specific questions/topics you want to do an internet search for and by now you should feel confident to identify trustworthy sources. I am always happy to help if you need more recommendations for sources or advice on whether a source is trustworthy.
As always, all work must be your own, and any material copied from another source must be clearly identified and the source cited.
1. Concept map of the human immune system
Concept maps are diagrams that connect sets of nouns via arrows labelled with verbs or verb phrases (https://en.wikipedia.org/wiki/Concept_map)
Create your own concept map of the innate immune response OR the adaptive immune response.
Include at least 20 relevant nouns/noun phrases (e.g. B-cell, macrophage, antigen)
Below is an example of a small section of a possible immune system concept map, so that you know what sort of thing to aim for (Attached in the additional materials section)
2. Zoom in on some immune system elements
Pick 3 of the nouns from your concept map, created in 1 (above). For each one provide at least 5 sentences or an original diagram, explaining what it is, and how it contributes to the human immune response to pathogens.
3. What’s happening during the immune response
Study the imagined graph of pathogen abundance over time, for a typical human-pathogen interaction (attached in the additional materials section). Then answer the questions below.
A – What would be different about the graph if this person lacked the ability to produce plasma cells, and why?
B – In at least 5 sentences, or an original diagram, what causes the pathogen level to drop and reduce to zero during the primary infection phase?
4. Antibody variability
The human genome encodes roughly 25,000 proteins, yet the B-cells of the average person have receptors capable of recognizing over 100 million different epitopes.
Using at least 5 sentences or an original diagram summarize the way that B-cell receptor/antibody variability is generated in an immature B-cell.
5. Immune disorders
Type I hypersensitivies can sometimes be cured by desensitization. In this process a patient is given very dilute doses of the allergen over months, allowing them to build up plasma cells to produce IgG antibodies. The IgG antibodies are then able to coat the allergen and stop it from binding to IgE antibodies elsewhere in the body.
Explain what a Type I Hypersensitivity is, how IgE antibodies are involved, and then connect this back to explain why desensitization can help reduce these hypersensitivities.
Use at least 5 sentences in your own words or an original diagram.


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