Momentum press.

Published by

Sep 23, 2022

s

Struggling with a similar assignment? Don’t know where to start? Don’t have time to work on this? Get a high-quality paper written for you from scratch – PLAGIARISM FREE, guaranteed to get you a good grade. To get started, please click on the Submit Your Instructions at the bottom of the page.

Tips for Posting
All writing and references must follow current American Psychological Association (APA) standards
Points will not be deducted for font, italicizing, and indentation in the discussion board
There are no “make-ups” for not posting to the Weekly Discussions
Avoid postings that are limited to ‘I agree’ or ‘great idea’, etc. If you agree (or disagree) with a posting, then say why you agree (or disagree) by supporting your statement with concepts from the readings or by bringing in a related example or experience
Address the questions as much as possible
Synthesize the readings into your own words (you may use quotes and paraphrasing from the articles as needed) to support your postings. Expand on your insights and reflect on the material.  Be sure to follow APA standards
Build on other responses to create threads
Go back and look at the responses posted to your Initial Post.  Your peers or the instructor may ask questions of you that you can answer as a Peer Response Post
Bring in related prior knowledge (work experience, prior coursework, readings, etc.) 
Use proper etiquette (address your peer by name, use professional language, etc.)
student 1stephanie
Good Morning Professor Raizer and class, 
Sickle cell disease is an inherited autosomal recessive disorder and chronic hemolytic anemia and that causes spleen dysfunction, heart issues, vision impairment, and most commonly intense pain and swelling to the extremities (Mkombachepa et al., 2022).  According to Eckdahl (2017), sickle cell disease (SCD) is most prevalent in sub-Saharan Africa, Central and South America, the Middle East, India, the Caribbean, and the Mediterranean.  SCD was first recognized in 1910 by a cardiologist James B. Herrick who recognized the sickle shape of the red blood cells (RBC) and coined the new blood disorder as sickle cell disease (Eckdahl, 2017). 
As research expanded, it was clear that many people who had SCD also lived in the above mentioned areas where malaria was a common occurrence.  It became clear that SCD is also an adaptive response against malaria.  The pathogen that causes malaria is plasmodium falciparum, a parasite that is transmitted from mosquitos and invades red blood cells and . Research revealed that patients who had the sickle cell trait had less of the parasite in their blood than others who suffered from malaria and did not carry the trait.  These patients also has less cumbersome symptoms when and if they became infected.  It seems as if the adaptation of the sickle cell trait was possibly due to three different reasons; the acidic environment created by the parasite, destruction of the sickled red blood cells in the spleen, and limited reproduction of the parasite due to export of potassium within the red blood cells (Eckdahl, 2017).  Families with ancestors from these areas are also more often noted to also suffer from sickle cell disease.  However, studies show that those who hold the heterozygotes hemoglobin S gene and carry the HBB allele and one abnormal hemoglobin allele have more resistance for malaria than those who hold the recessive homozygotes hemoglobin gene (Hb SS) (Mkombachepa et al., 2022). Due to the impaired splenic function of those with Hb SS have an increased risk of death from malaria.  This could be due to the removal of the spleen or the destruction of blood cells both infected with the parasite along with normal blood cells which exacerbates the anemia (Mwaiswelo et al., 2020).
While the genetic factor influences the severity of the disease, there are also important environmental factors that patients and families should be mindful of such as weather, air quality and pollutants, severe cold or high temperatures, high altitudes and low oxygen levels all can contribute to exacerbation of SCD (Eckdahl, 2017).  Treatment for mild cases of crisis is usually nonsteroidal anti-inflammagtory drugs which help to alleviate pain and decrease fever.  Drinking a lot of fluids, heating pads, massage and relaxation are good non-pharmacological methods to relieve symptoms during a sickle cell crisis.  Hydroxyurea is used to help increase the level of fetal hemoglobin (HbF) which results in decreased pain and other complications.  Should a patient need to be hospitalized, usual treatment includes oxygen therapy, intravenous fluids and opioids such as morphine or dilaudid to relieve pain (Eckdahl, 2017). 
References:
Eckdahl, T. T. (2017). Sickle cell disease: The evil spirit of misshapen hemoglobin. Momentum Press. http://doi.org/10.5643/9781944749767 (Links to an external site.)
Mkombachepa, M., Khamis, B., Rwegasira, G., Urio, F., Makani, J., & Luzzatto, L. (2022).  High incidence of malaria in patients with sickle cell disease. American Journal of Hematology, 97(1), E380-E381. https://doi.org/10.1002/ajh.26676  (Links to an external site.)
Mwaiswelo, R.O., Mawala, W., Iversen, P.O., de Montalembert, M., Luzatto, L., & Makani, J. (2020). Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum. Malaria Journal, 19(1), 1-5. https://doi.org/10.1186/s12936-020-03212-w
student 2 Zach
Good afternoon, 
Malaria is spread through the bite of a female anopheles mosquito. These mosquitos carry the parasite Plasmodium falciparum, which cause the malaria disease. This disease causes hypoxia in the body, leading to eventual death. In sickle cell disease, many red blood cells (RBC) have a sickled shape, which lead to vaso occlusion, pain, and other symptoms. However, these sickled cells alert macrophages which then attempt to destroy the sickled shape cells, causing anemia. However when it comes to malaria this is an advantage as the macrophages are eliminating RBCs that the immune system would not, assisting with the spread and severity of malaria in the body. This is the reason I believe that the adaptation occurred. Eleonore et al. (2020) showed that patients with sickle cell disease had a lower mortality than patients without it. 
When it comes to why do people who don’t live in malaria-prevalent area continue to develop sickle-cell disease, the answer is simple: genetics. Because sickle cell originated as a response for malaria, a disease prevalent in Africa, this trait was passed through the generations and has continued, despite these patients not living in a malaria-ridden area. 
From a provider perspective it is so important to provide these patients and their families with support throughout treatment or exacerbations, give proper education about the disease, and advise them to adhere to their health regimen that has been given to them (Schlenz et al., 2022). 
References:
Eleonore, N. L. E., Cumber, S. N., Charlotte, E. E., Lucas, E. E., Edgar, M. M. L., Nkfusai, C. N., Geh, M. M., Ngenge, B. M., Bede, F., Fomukong, N. H., Kamga, H. L. F., & Mbanya, D. (2020). Malaria in patients with sickle cell anaemia: burden, risk factors and outcome at the Laquintinie hospital, Cameroon. BMC Infectious Diseases, 20(1), 1–8. https://doi.org/10.1186/s12879-019-4757-x (Links to an external site.)
Schlenz, A. M., Phillips, S. M., Mueller, M., Melvin, C. L., Adams, R. J., & Kanter, J. (2022). Barriers and facilitators to chronic red cell transfusion therapy in pediatric sickle cell anemia. Journal of Pediatric Hematology/Oncology Nursing, 39(4), 209–220. https://doi.org/10.1177/27527530211073874
student 3 wendy
Good afternoon class and professor
Malaria is a parasitic illness caused by Plasmodium, a single-celled parasite. This parasite is transmitted to people, most commonly by mosquito bites (Sato, 2021). Malaria is transmitted to humans by the stings of an infected female Anopheles mosquito. Only Anopheles mosquitos can spread malaria; they must have previously consumed blood from an infected person to become infected. Malaria parasites enter the circulation and settle in the liver. When the parasites reach adulthood, they exit the liver and infect red blood cells. Malaria can be spread by transfusion, transplantation, or sharing infected needles. Because the malaria parasite resides in an affected person’s red blood cells, it poses a significant danger. 
Experts claim that the sickle cell disease gene emerged and departed in the population multiple times before becoming permanently fixed when a severe form of malaria was transferred from animals to people in Asia, the Middle East, and Africa. A mutation in the gene that codes for the beta globin chain of the hemoglobin molecule causes sickle cell anemia (Arishi et al., 2021). The mutation causes sickle-shaped hemoglobin to develop, which has the unusual ability to polymerize upon deoxygenation. 
Sickle cell anemia is still prevalent among persons with ancestors from Sub-Saharan Africa, India, Saudi Arabia, and Mediterranean nations. In the Americas, migration also boosted the frequency of the gene. Due to the scarcity of diagnostic facilities precise data are not available, an estimate suggests that about 80% of the global total of cases are from Sub-Saharan Africa. By comparison, the yearly estimate of affected births in North America is 2600 and 1300 in Europe (Wastnedge et al. 2018). As a result, it occurs through inheritance and migration mechanisms. 
Families with sickle cell anemia should obtain all recommended vaccines. It includes immunization against influenza, coronavirus, pneumococcal, and meningococcal illness, which is especially important for children. Folic acid supplements may be beneficial because they aid in producing new red blood cells. The doctor may prescribe hydroxyurea, blood transfusions to treat and avoid consequences from severe anemia, and stem cell transplants. Patients and caregivers should also educate themselves on the condition, treatment, and potential issues. 
 
References 
Arishi WA, Alhadrami HA, Zourob M. Techniques for the Detection of Sickle Cell Disease: A Review. Micromachines (Basel). 2021 May 5;12(5):519. doi: 10.3390/mi12050519. PMID: 34063111; PMCID: PMC8148117. 
Sato S. Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology. J Physiol Anthropol. 2021 Jan 7;40(1):1. doi: 10.1186/s40101-020-00251-9. Erratum in: J Physiol Anthropol. 2021 Jan 29;40(1):3. PMID: 33413683; PMCID: PMC7792015. 
Wastnedge E, Waters D, Patel S, Morrison K, Goh MY, Adeloye D, Rudan I. The global burden of sickle cell disease in children under five years of age: a systematic review and meta-analysis. J Glob Health. 2018 Dec;8(2):021103. doi: 10.7189/jogh.08.021103. PMID: 30574296; PMCID: PMC6286674. 

n

Need Writing Help? Our writing specialists are here 24/7, every day of the year, ready to support you! Instantly chat with an online tutor below or click here to submit your paper instructions to the writing team.

More than just an assignment.

GET THE GRADES YOU DESERVE | A OR A- GUARANTEED
NO MORE SLEEPLESS NIGHTS DOING RESEARCH
NO MORE LATE POINTS DEDUCTIONS 
GET A QUALITY PAPER SENT TO YOUR EMAIL
GET GOOD GRADES ON YOUR ASSIGNMENTS
Explore Now →

Who is this homework service for?

* If you are having a really hard class and want to get through it, then this is for you.

* If you have a medical emergency or someone close to you has a medical emergency and you don’t think you’ll be able to turn your assignment on time, this is definitely a service you could use.

* You can use us if you are having a tough Professor who won’t give you the grades you deserve.

* If you have a tight work schedule and you are getting points deducted for not submitting assignments on time.

* English might not be your first language and you feel like you are being left behind in class because of it.

* If you have a large project coming up and don’t think you have enough time to get it done well, definitely reach out to us.

TALK TO SUPPORT
{

Super stoked you are checking us out! We would like to help you with your assignment. We just need a few things from you:

* The full assignment instructions as they appear on your school account.

* If a Rubric is present, make sure to attach it.

* Any relevant weekly readings or learning resources.

* Include any special announcements or emails you might have gotten from your Professor regarding your assignment.

* Any templates or additional files required to complete the assignment.

If your assignment is somewhat complex and you need to explain it, please don’t hesitate to reach out to me via live chat. 

 

FAQ

Frequently asked questions

How soon can I get my paper done?

It depends with your deadline. If you need your paper completed in 3 hours, we will deliver it in that time. All you need to do is indicate your deadline in our custom order page here. Alternatively, if you are sending us your instructions via email, please be sure to indicate your deadline.

Will it be completely original? I don't want to be caught in a case of Academic Integrity Violation.

We are as paranoid as you are. Maybe even more! And we understand that the greatest sin you can commit in your academic journey is plagiarizing your academic work. To that end, we have made sure that we check and double-check our papers using high quality plagiarism detection tools such as SafeAssign and Turnitin before submitting the paper to you.

Who is my writer? Is he/she a native English Speaker?

All our writers are native English Speakers. That is not to say that ESL writers are not good, we just prefer hiring native writers because we want the very best people working on your paper. This might mean paying a little bit more for your paper as opposed to when you pay a foreign company whose writers are non-native English Speakers.

What if I need revisions? Will your charge additional for this?

Of course not! If you do happen to require a revision on your paper, our team will handle it for you free of charge. Matter of fact, we won’t rest till you are happy with your paper. So, ask for as many revisions as you need, it’s completely FREE!

Will you give me my money back if I don't like my paper?

We have very few instances where we delivered a paper that a client didn’t fall in love with. But if it so happens that you don’t like your paper for any reason whatsoever, we’ll refund your money back no questions asked.

I have more assignments after this, can you help me with those too?

Of course! And what’s even better is that we can reserve a writer permanently to work on your entire class. This comes in handy for projects which build up on each other and where you need just one writer, one writing style.

I got my order information wrong, can I change that?

Yes you can. Just reach out to our support team via email (support@essaynook.com) or live chat here and they’ll help you change the instructions.

Can I place an order via email instead of going through the order page?

Yes you can. Email Anna at anna@essaynook.com, she’s in charge of our sales team. Alternatively, you can talk to our Live Chat team here and request to speak to Anna.

Trusted by Thousands of Students

Delivering quality assignments since 2007

%d bloggers like this: